(INN - Codeine) - 8 mg, sodium bicarbonate - 200 mg, licorice root in powder form - 200 mg, lanceolate thermopsis herb - 20 mg; additional substances: potato starch, talc, microcrystalline cellulose.

Composition of Codelac Phyto syrup: 5 ml contains codeine phosphate – 4.5 mg, dry thermopsis extract – 0.01 g, thick licorice root extract – 0.2 g, liquid thyme extract – 1 g; additional substances: sorbitol , nipazole , nipagin , water.

Release form

As tablets, yellow or brown, which may have inclusions of white or dark brown. 10 pcs. in contour packages, 1 or 2 packages in a cardboard box.

Codelac cough syrup Phyto brown in color, with an aromatic odor, placed in dark glass bottles of 50, 100, 125 ml.

pharmachologic effect

The medicine is a combined antitussive drug.

Codeine has an antitussive effect of central origin, reducing the excitability of the cough center.

Included thermopsis herbs contains alkaloids that increase bronchial secretion and accelerate its evacuation, thereby providing an expectorant effect.

Sodium bicarbonate alkalizes bronchial mucus, reduces the viscosity of sputum, activates the motility of the bronchial epithelium.

Liquorice root has an expectorant effect. It has an antispasmodic effect on smooth muscles and an anti-inflammatory effect.

Thyme herbal extract consists of a mixture of essential oils, which, by enhancing the activity of the ciliated epithelium of the mucous membrane of the upper respiratory tract, increasing the amount of secretion, diluting sputum and accelerating its evacuation, have an expectorant, anti-inflammatory, and bactericidal effect. Additional effects of thyme are also mild antispasmodic and healing.

Pharmacodynamics and pharmacokinetics

The drug stimulates the secretion of mucus from the respiratory tract and reduces cough.

The onset of the maximum effect is within 30-60 minutes, duration is up to 6 hours.

No pharmacokinetic data available.

Indications for use

As symptomatic therapy dry cough for diseases of the bronchopulmonary system.

Contraindications

  • and the period of breastfeeding;
  • children under 2 years old;
  • use of centrally acting analgesics;
  • respiratory failure;
  • consumption;
  • individual intolerance to the components of the drug.

Side effects

  • Digestive system: nausea, constipation, vomiting.
  • Nervous system: drowsiness, headache.
  • In the form of an allergy: skin itching, rashes.

Instructions for use of Codelac (Method and dosage)

Codelac tablets taken orally, 2 to 3 times a day, 1 tablet, for several days.

Maximum single dose codeine for adults – 0.05 g, daily – 0.2 g.

In patients with impaired renal function, the interval between taking the drug should be increased, since their elimination of codeine is slower.

Instructions for Codelac Phyto cough syrup determines the daily dose of syrup according to age:

  • children 2 - 5 years old - 5 ml;
  • from 5 to 8 years, 10 ml;
  • 8 – 12 years – 10-15 ml;
  • from 12 years old and adults – 15-20 ml.

The dose must be divided into 3 doses. The syrup is taken between meals. Therapy is carried out briefly, over several days.

Overdose

Symptoms are: drowsiness, skin itching, slow breathing, arrhythmias, slow heartbeat, vomiting, bladder atony.

Treatment includes gastric lavage, symptomatic therapy, and , which is an antagonist codeine . If necessary, measures are taken to restore breathing and the activity of the cardiovascular system.

Interaction

Simultaneous use with drugs that depress the nervous system (sedatives, antihistamines, hypnotics, centrally acting analgesics, antipsychotics, anti-anxiety drugs) is not recommended, since it threatens to increase the sedative effect and suppress the respiratory center.

Enveloping and absorbent agents reduce absorption codeine from the gastrointestinal tract.

Terms of sale

Codelac tablets- over the counter.

Syrup- on prescription.

Storage conditions

Keep away from children and in a dry place. Tablets at temperatures up to 25°C, syrup - not less than 12 and not higher than 15°C.

Best before date

Pills- 4 years.
Syrup– 1 year and 6 months.

special instructions

Use with great caution in persons with increased intracranial pressure.

Long-term use of the drug can lead to the development drug addiction .

Do not administer simultaneously with mucolytics and expectorants.

Before using antitussive drugs, it is necessary to accurately determine the cause of the cough and, if necessary, use special treatment.

Since the drug with codeine - is doping.

The drug may have a sedative effect; driving is not recommended.

Analogues

Level 4 ATX code matches:

For children

Use for children under 2 years of age is contraindicated.

With alcohol

When taken simultaneously, codeine enhances the effect of ethanol on psychomotor reactions, so drinking alcohol while taking the drug is prohibited.

During pregnancy and lactation

Reception is contraindicated.

Reviews about Codelac

Numerous reviews on Codelac Phyto they say that the drug is quite effective. Most patients, having tried all kinds of cough tablets, only received improvement from Codelaca. Many mothers leave reviews of Codelac Fito for children as a mild drug, with good tolerability and quick cough relief. Some reviews note the sedative effect as a plus - thanks to this, children sleep better at night.

When choosing treatment, you must always remember what kind of cough Codelac is for - take only for dry cough.

Codelac price, where to buy

Price Codelac tablets in Russia is 143 rubles, the price for Codelac Phyto syrup– 146 rub.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Kazakhstan Kazakhstan

ZdravCity

    Codelac NEO syrup 1.5 mg/ml 200 ml

    Codelac Broncho with thyme elixir 100mlPharmstandard-Leksredstva OJSC

    Codelac NEO syrup 1.5 mg/ml 100 mlPharmstandard-Leksredstva OJSC

    Codelac NEO drops for internal use. approx. 5mg/ml 20mlOJSC "Pharmstandard-Leksredstva"

The composition of the drug Coldact includes active ingredients – 0.5 g + Chlorpheniramine maleate – 0.08 g and additional substances that make up the gelatin shell.

Included Coldact Flu Plus active ingredient capsules: paracetamol – 0.2 g; – 8 mg; – 25 mg and excipients ( hypromellose, MCC, talc, ethylcellulose, povidone, diethyl phthalate, dyes, sucrose, water, sodium disulfite, starch syrup, disodium edetate, granulated sugar).

Suspension Flu Plus contains active ingredients: chlorphenamine maleate – 2 mg; paracetamol – 0.125 g; phenylephrine hydrochloride – 5 mg + carmellose sodium, propyl parahydroxybenzoate, disodium edetate, methyl parahydroxybenzoate, sodium saccharinate, sodium chloride, MCC, glycerin, sucrose, xanth gum, silicon dioxide, flavorings, polysorbate 20, sodium citrate, water, citric acid.

Release form

Coldact released in capsules long-acting in a gelatin shell, packs of 10 pieces.

Coldact Flu Plus- in two forms:

  • shelled capsules made of gelatin, half red, half transparent, inside - yellow, red and white pellets, in packs of 10-100 pieces;
  • suspension for internal use, viscous, orange, with a specific odor, in a bottle of 60 ml.

pharmachologic effect

Antihistamine action , constricts blood vessels. Anticongestive .

Flu Plus also has antipyretic And painkillers action.

Pharmacodynamics and pharmacokinetics

Included in the tablet Coldact And Koldakt Plus chlorpheniramine is the most effective antihistamine , reducing the impact on H1 receptors . Also has minor sedative And antimuscarinic Effect. The substance has the ability to reduce the permeability of mucosal cells in the nose, thereby reducing unpleasant symptoms (itching and swelling).

The process of interaction with blood plasma occurs slowly. The maximum concentration is after 2-6 hours, metabolized in the body. However, a small part of it is excreted by the kidneys.

Other active ingredient - phenylpropanolamine is symptomatomimetic . Affects alpha adrenergic receptors , but to a lesser extent than, for example, . Possesses vasoconstrictor, anti-edematous effect on the mucous membrane of the nose and paranasal sinuses.

Reaches maximum concentration within 2 hours. Excretion is carried out through the kidneys.

Reduces body temperature and relieves pain. Helps eliminate cold symptoms - headaches, pain in joints and muscles, discomfort in the throat.

It binds poorly to blood proteins, less than 10%, is metabolized in the liver, maximum concentration is after 3 hours. Excretion occurs in the urine within 24 hours after administration.

Indications for use

  • (vasomotor or allergic );
  • relief of cold symptoms such as allergization, swelling, runny nose, stuffy nose .

Contraindications

The suspension can be taken by children from 6 years of age.

Flu Plus has a number of additional contraindications:

  • severe forms of kidney, liver, heart, gall bladder diseases;

Side effects

Doesn't happen often:

  • drowsiness, headache, overexcitation and excessive irritability;
  • hepa- And nephrotoxic impact;
  • dry mouth, diarrhea, nausea, loss of appetite ;
  • increase, vision problems;
  • chest pain, dysuria ;
  • pain in epigastric region , loss of appetite.

Instructions for Koldakt (Method and dosage)

The duration of administration and dosage should be prescribed by a doctor.

According to the instructions for use of Koldakt, adults are prescribed 2 capsules per day, divided into 2 doses.

The course of treatment is from 1-3 ( , ) up to 30 days.

Instructions for use Coldact Flu Plus

According to the instructions for Coldact Flu Plus, two capsules are prescribed per day, at regular intervals.

The syrup should be shaken well before use.

Adults are prescribed 30-40 ml per day, in 3-4 doses. Children from six years old – 15-20 ml, in 3-4 doses.

The course of treatment, as a rule, is no more than five days.

Overdose

No cases have been reported. Therapy - according to symptoms.

For the form that includes paracetamol, the symptoms are: nausea, hepatonecrosis , pallor and weakness, loss of appetite. See a doctor as soon as possible and rinse the stomach, administer SH-group donors , methionine (first 8 hours) or N- (12 hours).

Interaction

Use with caution in combination with MAO inhibitors, tricyclic antidepressants, halothane, guanethidine,

Latin name: Coldact Flu Plus
ATX code: N02B E51
Active substance: paracetamolum
phenylephrinum, chlorphenaminum
Manufacturer: NATUR PRODUCT EU
(Netherlands), RANBAXY (India)
Conditions for dispensing from a pharmacy: Over the counter

Coldact Flu Plus is a complex drug that helps cope with the symptoms of colds. Facilitates breathing, eliminating nasal congestion and discharge, reduces temperature, pain syndromes, and allergy symptoms. Lorpils differs from the previous drug Koldakta in its dosage form - it is available in capsules with a prolonged action.

Indications for use

The drug is used in symptomatic therapy, as a means of first aid, and also to relieve certain symptoms of illness - various types of pain, fever, fever. It is used to relieve symptoms of influenza, acute respiratory infections, ARVI, allergic and vasomotor rhinitis.

Composition of the drug

One capsule of the medicine contains: 200 mg of paracetamol, 8 mg of chlorphenamine (in the form of maleate), 25 mg of phenylephrine (in the form of hydrochloride).

Other components of the drug are talc, ethylcellulose, povidone, hypromellose, water, sodium compounds, food coloring, gelatin and other substances. The filling of the capsules is made of sucrose and molasses.

Medicinal properties

The therapeutic effect of Coldact Flu is due to the properties of its active components:

  • Paracetamol has antipyretic, analgesic and mild anti-inflammatory properties. The substance inhibits prostaglandins and affects the part of the brain responsible for thermoregulation of the body. Thanks to this action, after taking the drug, the temperature decreases and various types of pain characteristic of colds are relieved.
  • Phenylephrine has a vasoconstrictor effect and has an antiallergic effect. Mainly used to eliminate and prevent congestion. The substance relieves swelling and inflammation of the mucous tissues of the respiratory tract and sinuses.
  • Chlorphenamine is an antihistamine. It affects certain receptors and thereby eliminates allergic reactions - reduces nasal discharge and lacrimation.

The therapeutic effect of the drug manifests itself within an hour after administration and persists throughout the day.

Release forms

Average cost – 180 rubles.

Extended-release capsules are hard gelatin pills in a transparent shell, one part of which is colorless, the other is bright red. The contents of the capsules are multi-colored granules. The product is packaged in 10 pieces per contour package. A cardboard pack contains one plate and an insert-annotation.

Mode of application

  • Children (12+) and adults take one capsule every 12 hours. The course of treatment is 3-5 days.
  • If the product is used to reduce fever, then it can be used for no more than 3 days, and as a pain reliever - no more than 5.

It is not recommended to independently prolong the use of Koldakt or increase its dose. Further use of the drug must be agreed with your doctor.

During pregnancy and breastfeeding

Contraindications

Coldact Flu should not be taken if you have:

  • Individual hypersensitivity to at least one component
  • Children's age (up to 12 years)
  • Diabetes
  • Peptic ulcers of the gastrointestinal tract
  • Arterial hypertension
  • Severe pathologies of the liver, kidneys
  • Heart diseases
  • Bladder problems
  • Overactive thyroid gland (thyrotoxicosis)
  • Blood diseases, hematopoietic disorders
  • Pathologies of the pancreas
  • Angle-closure glaucoma
  • Anemia
  • G-6-PD deficiency
  • Atherosclerosis of the coronary arteries.

For bronchial asthma and COPD, taking the medication should be agreed with a doctor and carried out under his supervision.

Precautionary measures

Considering that Koldakt contains paracetamol, you should be careful when taking it:

  • If other drugs are taken with paracetamol at the same time, it is necessary to monitor their dosage so as not to exceed the daily dose of the substance.
  • You should not take the drug without a medical prescription if the patient must take MAO inhibitors.
  • When treating with Koldakt, you should avoid alcoholic beverages and alcohol-containing medications.
  • If you take drugs for a long time, you will need to check your blood counts and liver condition.
  • During Koldakt therapy, it is advisable to refrain from driving or operating machinery that requires quick reaction and concentration.
  • The medicine may cause bronchospasm in people intolerant to acetylsalicylic acid.

If after using the medication the condition does not improve, persists, or even worsens, you should definitely consult a therapist.

Cross-drug interactions

When taking Coldact Flu, you should remember that its components react with substances of other drugs:

  • When combined with Metoclopramide, the absorption of paracetamol increases, and when taken with Cholestyramine, it worsens.
  • Coldact can slow down the removal of antibiotics from the body and reduce the effect of diuretics.
  • Anticonvulsants increase the toxic effects of paracetamol on the liver.
  • The effect of chlorpheniramine increases when taken with drugs that affect the functioning of the brain (hypnotics, sedatives, tranquilizers, barbiturates, etc.). The substance itself enhances the effect of antispasmodics, drugs for the treatment of parkinsonism, and some antidepressants.
  • Phenylephrine can provoke a hypertensive crisis or arrhythmia if used with adrenergic agonists and MAO inhibitors.

Side effects

As a rule, Koldakt is normally perceived by the body. Undesirable side effects appear as:

  • Nausea, heartburn, vomiting, dry mouth
  • Decreased appetite
  • Abdominal pain
  • Stool disorders, urinary retention (occasionally), flatulence
  • Difficulty breathing, pain in the heart area
  • Skin reactions, angioedema (rare)
  • Lethargy, dizziness and headache
  • Increased irritability, nervousness
  • Tinnitus
  • Visual impairment, dry eyes, increased intraocular pressure
  • Anaphylactic shock
  • Tachycardia, shortness of breath
  • Increased blood pressure.

If any discomfort develops, the drug should be discontinued and consult a doctor.

Overdose

Taking too high doses of Koldakt can cause unpredictable consequences. Therefore, if an overdose of a medicine occurs, you should not hesitate to consult a doctor - you must call an ambulance as quickly as possible, regardless of whether there are symptoms of poisoning or not.

Symptoms of paracetamol intoxication develop if the drug content exceeds 10-15 g. Overdose manifests itself:

  • Pale skin
  • Nausea, bouts of vomiting
  • Abdominal pain
  • Dizziness
  • Nervous excitement
  • Disorientation
  • Insomnia.

Failures in the functioning of the heart and the development of pancreatitis are also possible.

In the case of simultaneous use of alcohol and Coldact Flue tablets, severe liver dysfunction develops, which, if the condition worsens, can provoke a coma and then death. Moreover, signs of organ damage may not be felt for 12-48 hours after taking the pills.

If the patient has taken high doses for a long time, then the overdose manifests itself in the form of aplastic anemia, a decrease in blood components, and a decrease in their concentration.

An overdose of finilephrine and chlopheniramine is manifested by severe sweating, nervous agitation or depression, headaches, drowsiness, confusion, high blood pressure, rapid heartbeat, and convulsions.

Conditions and shelf life

The drug is suitable for use for 2 years from the date of production. To avoid loss of medicinal properties, it must be stored in a dark place, away from heat and inaccessible to children, at temperatures up to 25 ° C.

Analogues

To select an identical remedy with a similar action and therapeutic effect, you need to contact a doctor.

Novartis (Türkiye)

Price– 165-230 rub.

The drug contains the same components as Koldakt and has a similar effect. Approved for use by adults and adolescents from 12 years of age.

The drug is available in the form of coated tablets. Packaged in blister packs of 10 pieces. The application scheme differs from Koldakt:

  • Adults are allowed to drink 1-2 pieces. after 4-6 hours (maximum - 6 tablets per day)
  • Children and teenagers (12-18 years old) – 1 pc. once every 4-6 hours (maximum – 4 tablets).

Advantages:

  • High efficiency
  • It works quickly.

Flaws:

  • Many contraindications
  • It is necessary to monitor the intake of other medications
  • Side effects.

Coldact Flu Plus is a combination drug characterized by a prolonged action. It has a powerful anti-allergic and anti-inflammatory effect. Instructions for use of Coldact Flu Plus will describe in detail when you can take this medicine.

With this drug you can quickly get rid of a runny nose, sore throat, and watery eyes. Coldact Flu Plus is also intended to eliminate pain. The use of this medicine allows you to reduce body temperature, as well as get rid of swelling and hyperemia of the upper respiratory tract.

Coldact Flu Plus is a medicine designed to relieve symptoms of influenza and ARVI. It also has an analgesic effect. It is prescribed against:

  • Sore throat;
  • runny nose;
  • swelling of the mucous membrane;
  • sinusitis, tracheitis, pharyngitis;
  • hay fever;
  • lacrimation;
  • high temperature;
  • fever and pain syndrome;
  • allergic rhinitis.

The effectiveness of Coldact Flu Plus is due to its specific composition. It is completely safe and, when used correctly, cannot cause serious harm to the body. The basis of the drug is:

  • Chlorphenamine – relieves itching in the eyes and nose, fights lacrimation, has an antiallergic effect;
  • paracetamol is an antipyretic and anti-inflammatory drug that helps get rid of pain in the throat, muscles and joints;
  • phenylephrine – relieves swelling and hyperemia of the mucous membranes of the upper respiratory tract.

Coldact Flu Plus is slowly absorbed from the gastrointestinal tract. Already 2-6 hours after consumption, its maximum concentration in the blood reaches.

45% of the components are bound by blood proteins. The active substance is completely eliminated from the body after 30 hours along with urine.

Release forms

Instructions for use

Coldact Flu Plus is intended for internal use. It should be consumed only after meals so as not to irritate the gastric mucosa. For acute respiratory viral infections and influenza, capsules should be taken once every 12 hours, and the duration of therapy should not exceed 3 days.

To treat rhinitis, capsules are also prescribed, which must be taken 3 times a day for 6-12 days. If you use Coldact Flu Plus as an antipyretic, you can do this for no more than 5 days.

For allergic rhinitis, Coldact Flu Plus capsules are taken for 3-6 days, 1 piece every 8 hours. When treating chronic rhinitis, the duration of treatment should be at least a month. Coldact Flu Plus can be used as a pain reliever for no more than 5 days.

Coldact Flu Plus can also be used in the form of a suspension. Before use, it must be shaken thoroughly so that the settled active ingredients dissolve. You should take the medicine as follows:

  • 2 teaspoons - children over 12 years old and adults;
  • 1 teaspoon – for children from 6 to 13 years old.

Contraindications

  • Severe arterial hypertension;
  • difficulty urinating;
  • atherosclerosis of the coronary arteries;
  • diabetes mellitus;
  • recent myocardial infarction;
  • allergies and hypersensitivity to the components of the drug;
  • angle-closure glaucoma;
  • aortic aneurysm;
  • unstable angina;
  • thyrotoxicosis;
  • pregnancy and lactation.

Also, doctors do not prescribe Coldact Flu Plus to children under 12 years of age, the elderly, or during concurrent therapy with tricyclic antidepressants or MAO inhibitors.

People with renal or liver failure, congenital hyperbilirubinemia, Rotor, Dubin or Gilbert syndrome, chronic obstructive pulmonary disease or bronchial asthma may take the medicine with extreme caution.

Dosage

Coldact Flu Plus in all produced dosage forms has only one dosage.

  • Capsules – contains 200 mg of paracetamol, 25 mg of phenylephrine and 8 mg of chlorphenamine. Additionally, the composition of the drug includes granulated sugar, sucrose and starch syrup.
  • Suspension (5 ml) – contains 125 mg of paracetamol, 5 mg of phenylephrine, 2 mg of chlorphenamine. Additionally, sodium citrate, citric acid, glycerin and sucrose are present.

Side effects

Coldact Flu Plus rarely causes side effects. Sometimes patients experience:

  • Hives, skin rash, itching and peeling;
  • angioedema;
  • nausea and vomiting;
  • stomach ache;
  • agranulocytosis;
  • increased blood pressure;
  • insomnia;
  • dizziness and headache;
  • increased excitability;
  • dry mouth and urinary retention;
  • iron deficiency anemia, agranulocytosis, thrombocytopenia;
  • accommodation paresis;
  • increased pressure inside the eye.

With long-term use of Coldact Flu Plus in people who have hypersensitivity to the components of the drug, hemolytic or aplastic anemia, nephrotoxicity, papillary necrosis, renal colic, interstitial nephritis, glycosuria, methemoglobinemia or pancytopenia may occur.

Price

Coldact Flu Plus can be easily purchased at any pharmacy. The average cost of capsules is 150-290 Russian rubles, one bottle of suspension is 100-180.

Analogues

Analogs for the active substance (paracetamol, phenylephrine, chlorphenamine):

  • Anacold;
  • TheraFlu Extratab;
  • Lorraine;
  • AntiFlu;
  • Lorraine plus;

Cheap analogues of Coldact Flu Plus:

  • Vicks active symptomax– intended for the treatment of cold and flu symptoms. The approximate cost at the pharmacy is from 30 to 60 Russian rubles.
  • Brustan– relieves inflammatory processes in the body, relieves pain. Can be used as symptomatic therapy for myositis, fibrositis, fractures and other lesions. The approximate cost at the pharmacy is from 50 to 90 Russian rubles.
  • Gripgo– fights symptoms of influenza and other viral diseases. Reduces body temperature and relieves pain. The approximate cost at the pharmacy is from 12 to 55 Russian rubles.
  • Gripout– intended for the treatment of acute and respiratory viral diseases. Effectively fights high fever and runny nose. The approximate cost at the pharmacy is from 40 to 90 Russian rubles.
  • Gripflu– intended for the treatment of infectious diseases of the upper respiratory tract. Also helps reduce body temperature. The approximate cost in pharmacies is 15 to 40 Russian rubles.

Overdose

If you take Coldact Flu Plus according to the instructions, the risk of overdose is minimal. It occurs only when taking 10 grams of medication or more at the same time. This phenomenon can be recognized by pale skin, nausea and vomiting, decreased appetite, dizziness, apathy, excessive transaminase activity and an increase in antithrombin time.

To minimize the negative consequences of a drug overdose, it is necessary to perform gastric lavage. After this, donors of SH groups and methionine precursors are introduced. In case of overdose, you must immediately call a doctor, regardless of whether there are signs of it or not.